Clinically Relevant Genetic Variations in Drug Metabolizing Enzymes
نویسندگان
چکیده
منابع مشابه
Variability in Mass Spectrometry-based Quantification of Clinically Relevant Drug Transporters and Drug Metabolizing Enzymes.
Many different methods are used for mass-spectrometry-based protein quantification in pharmacokinetics and systems pharmacology. It has not been established to what extent the results from these various methods are comparable. Here, we compared six different mass spectrometry-based proteomics methods by measuring the expression of clinically relevant drug transporters and metabolizing enzymes i...
متن کاملPhase II drug metabolizing enzymes.
BACKGROUND Phase II biotransformation reactions (also 'conjugation reactions') generally serve as a detoxifying step in drug metabolism. Phase II drug metabolising enzymes are mainly transferases. This review covers the major phase II enzymes: UDP-glucuronosyltransferases, sulfotransferases, N-acetyltransferases, glutathione S-transferases and methyltransferases (mainly thiopurine S-methyl tran...
متن کاملClinically relevant variations in the origin and course of the radial artery
Background: The radial artery is an essential artery supplying the structures in the forearm. Variations in the radial artery concerning its origin, course, branching pattern, and mode of termination have been commonly reported. The high origin of the radial artery from either brachial or axillary artery was detected in numerous studies. Clinically-radial artery is used in cardiac catheterizati...
متن کاملUpdate on the Genetic Polymorphisms of Drug-Metabolizing Enzymes in Antiepileptic Drug Therapy
Genetic polymorphisms in the genes that encode drug-metabolizing enzymes are implicated in the inter-individual variability in the pharmacokinetics and pharmaco-dynamics of antiepileptic drugs (AEDs). However, the clinical impact of these polymorphisms on AED therapy still remains controversial. The defective alleles of cytochrome P450 (CYP) 2C9 and/or CYP2C19 could affect not only the pharmaco...
متن کاملClinically relevant variations of the coeliac trunk.
INTRODUCTION Vascular patterns are important in the planning and performance of all upper abdominal surgical procedures. The coeliac trunk arises from the abdominal aorta and supplies the supracolic organs. Knowledge of variations of the coeliac trunk is important in procedures such as liver transplants for appropriate vascular ligation and anastomosis. METHODS The branching patterns of the c...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Drug Metabolism
سال: 2011
ISSN: 1389-2002
DOI: 10.2174/138920011795495321